Doubt it. More like a replacement for Rudiger while he is out injured and they need more cover at CB and at LB too. If Roma are playing hard ball over Nainggolan, they will do the same with Manolas.
However saying that, if they by Nacho, they may be willing to sell however I imagine they will want huge money for him but he would be worth it. Sick and tired of getting excited by potential deals only to see it be thwarted.