In moments against Brighton it looked like 4-4-2 with RLC going up. Frank just told him that to convince him to come
On a serious note Giroud - Werner could be nice combo.
There are different set ups in 4-4-2 as well. With wide players it could look like 4-2-4. But you can also play without wide players like legendary AC Milan with Gattuso, Seedorf, Pirlo and Kaka.
In this case I think:
Havertz
Kovacic Kante
Jorginho
Would be nice option when Pulisic and Ziyech are not fit like now...