Don't see the 4-2-2-2 as a long term solution. leaves the wings too vulnerable. I think it was more a one-off to surprise spurs and dominate their dogged midfield. Obviously it depends how wide the no.10s go in the transition but IMO it helps when there are designated wingers. Also I think if you have a good no.10, one is enough.
4-2-3-1 might be a good shout vs Palace. It's actually my favourite system to play in games where you are not the underdog bc of the security it gives in the middle and the versatility of options in the channels. We are just missing actual wingers for it to be maximally effective. Pulisic and CHO are our only actual wingers. Mount and Ziyech are too slow and Werner is not technical enough.