Lyon have four main threats - Benzema's speed, Ben Arfa's close control, Fred's finishing and first and foremost - Juninho Pernambucano's free-kicks. If Man United prevent these factors, they have the tie won.
Us, United and Liverpool are as good as through in my opinion, Liverpool will hold out to win the tie on aggregate in Milan. United will unlocky Lyon to beat them and we should obliterate Olympiakos with any luck.
I wouldn't be surprised. The players are not idiots, they know Grant came in to gradually push Mourinho out of the door. José was their idol and inspiration, Grant doesn't even compare in their eyes anymore. After every good performance comes a poor one, its an emergin pattern.
That hammering at the Theatre of Dreams seems to have knocked the wind out of their sails. On the other hand, Arsenal are a great team and should recover, unless they get mauled at the Giuseppe Meazza against Milan, at which point I think they'll crumble. There is only so much beating a team can take.